Akses Data Kajian

Sila isikan maklumat di bawah untuk melihat dokumen kajian klinikal sepenuhnya.

Sedang memproses... Sila tunggu sebentar.

Eurycoma longifolia Clinical Studies

No. Title Subject Dose Benefit Reference/Authors Link
1 Standardized water soluble extract of Eurycoma longifolia (LJ100)/ Phytsa related clinical study Male volunteers of different ages and health status 200mg, 400mg & 600mg
  • Majority showed Sexual Health Inventory for Man (SHIM) scores was elevated to upper normal from the first week.
  • Non-toxic at high dose of 600mg
  • Improvement in HDL
  • Significant effect on lowering blood glucose levels (in diabetic)
 Tambi, M.I. Free Communications- F07. International Journal of Andrology (2005). Vol. 28(Suppl 1):25-44. No Link
2 Effect of Eurycoma longifolia extract on anabolic balance during endurance exercise Athletes 100mg
  • Maintain normal levels of cortisol (low) and testosterone (high) *elevated cortisol and suppressed testosterone during intense endurance exercise.
 Talbott, S., & George, A. 2024. Andrologia View Study
3 Water soluble extract of Eurycoma longifolia Jack as a potential natural energizer for healthy aging in men. Married men (31-52 years) 200mg
  • Majority showed increased sexual desire and the success in the attempts at sexual intercourse (SHI and PADAM score)
  • Increase testosterone and free testosterone levels
 Tambi, M.I.M., Othman, S. and Saad, J.M.*Unpublished No Link
4 Eurycoma longifolia Jack in managing idiopathic male infertility Men with idiopathic infertility 200mg
  • Improvements in sperm parameters of 75 men
  • 11 recorded spontaneous pregnancies (14.6%)
 Tambi, M.I. & Imran, K. Asian Journal of Andrology (2010). 12:376-380 View Study
5 Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Men with late-onset hypogonadism (LOH) 200mg
  • Significant improvement in AMS score and serum testosterone concentration
 Tambi MI, Imran MK, Henkel RR. Andrologia (Jun 15, 2011) doi: 10.1111/j.1439-0272.2011.01168.x. pg 1-5. View Study
6 Effects of a Proprietary Freeze-dried Water Extract of Eurycoma longifolia on Sexual Performance and Well-being in Men with Reduced Sexual Potency Men with mild erectile dysfunction 200mg
  • Significant higher scores than the placebo group following endpoints: Erection Hardness Scale score, Active Males Symptom Score, and the Sexual Health Inventory for Men
  • The Sexual Intercourse Assessment (SIA) showed statistical significant higher than the Placebo group for a few scores
 Udani J, Gruenwald J, Miller M, George A, Mufiza M, Abas A (2011). Abstract presented at the ‘Natural Supplements: An Evidence-Based Update’ conference... View Study
7 Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men Men (30 - 55 years) 300mg
  • Significant improvement in the domain Physical Functioning of SF-36 (BG, WG)
  • Higher scores in the overall Erectile Function domain in IIEF, sexual libido (14% by week 12), SFA- with sperm motility at 44.4%, and semen volume at 18.2% at the end of treatment
  • Subjects with BMI ≥ 25 kg/m2 significantly improved in fat mass lost
 Ismail, S. B., Wan Mohammad, W. M. Z., George, A., Nik Hussain, N. H., Musthapa Kamal, Z. M., & Liske, E. (2012). Evidence‐based Complementary and Alternative Medicine. View Study
8 Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. Men & Women with moderate stress 200mg
  • Significant improvements for Tension (-11%), Anger (-12%), and Confusion (-15%)
  • Significant improvement in stress hormone profile with reduced cortisol exposure (-16%) and increased testosterone status (+37%).
 Talbott, S. M., Talbott, J. A., George, A., & Pugh, M. (2013). Journal of the International Society of Sports Nutrition, 10(1), 28. View Study
9 The Eurycoma Longifolia Freeze-Dried Water Extract-Physta® Does not Change Normal Ratios of Testosterone to Epitestosterone in Healthy Males. Men (30 - 55 years) 300mg
  • T/E-ratio in the herbal group not significantly different from values at baseline
  • Ratio-values for E. longifolia compared to placebo did not change over time
  • Weight lifting force increased significantly from baseline to end of the study in the herbal group (14 kg)
 George, A., Liske, E., Chen, C. K., & Ismail, S. B. (2013). J. Sports Med. Doping Stud, 3, 1000127. View Study
10 Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors - A Pilot Study. Male & Female - physically active seniors (57-72 years) 400mg
  • Hemoglobin, testosterone and dihydroepiandrosterone concentration, ratio of total testosterone/cortisol and muscle force remained significantly lower in the females than in the males
  • Hematocrit and erythrocyte count in males increased slightly, but were significantly higher than in females
  • In both men and women, treatment resulted in significant increases in total and free testosterone concentrations and muscular force.
 Henkel, R. R., Wang, R., Bassett, S. H., Chen, T., Liu, N., Zhu, Y., & Tambi, M. I. (2014). Phytotherapy Research, 28(4), 544-550. View Study
11 Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men. Men (40–65 years) 200mg TA + 100mg Kesum
  • Significant improvements in scores for the Sexual Intercourse Attempt diary, Erection Hardness Scale, Sexual Health Inventory of Men, and Aging Male Symptom scale
 Udani, J. K., George, A. A., Musthapa, M., Pakdaman, M. N., & Abas, A. (2014). Evidence‐Based Complementary and Alternative Medicine, 2014(1), 179529. View Study
12 Supplementation of Eurycoma longifolia Jack Extract for 6 Weeks Does Not Affect Urinary Testosterone: Epitestosterone Ratio, Liver and Renal Functions in Male Recreational Athletes. Healthy male recreational athletes 400mg
  • T:E ratio was not significantly different for both active and placebo compared with their respective baseline values.
 Chen, C. K., Mohamad, W. M. Z. W., Ooi, F. K., Ismail, S. B., Abdullah, M. R., & George, A. (2014). International Journal of Preventive Medicine, 5(6), 728. View Study
13 Immunomodulation in Middle-Aged Humans Via the Ingestion of Physta® Standardized Root Water Extract of Eurycoma longifolia Jack... Middle age men & women 200mg
  • SIV and immunological grade were significantly higher
  • Immunological grade showed improvement
  • Numbers of total, naïve, and CD4+ T cells higher in the TA group than those in placebo group
  • HDL cholesterol and triglycerides showed improvement in TA group
 George, A., Suzuki, N., Abas, A. B., Mohri, K., Utsuyama, M., Hirokawa, K., & Takara, T. (2016). Phytotherapy Research, 30(4), 627-635. View Study
14 Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study Moderately stressed healthy participants 50mg
  • Improvement in SF-12 QoL, POMS and MMSQ domains (WG)
  • Significant increase in lymphocytes in the active group
 George, A., Udani, J., Abidin, N. Z., & Yusof, A. (2018). Food & Nutrition Research, 62, 10-29219. View Study
15 Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women... Women (41–55 years) with peri-menopausal or menopausal symptoms 200mg KF + 50mg TA
  • Significant improvement in hot flush symptoms at week 12
  • Significant improvements in MRS and MENQOL scores at weeks 12 and 24 were observed in both groups, respectively
  • Luteinising hormone and follicle-stimulating hormone levels were significantly reduced at weeks 12 and 24, respectively
  • Significant reductions in serum low-density lipid and triglycerides levels at week 12
 Chinnappan, S. M., George, A., Evans, M., & Anthony, J. (2020). Food & Nutrition Research, 64, 10-29219. View Study
16 Effect of Eurycoma longifolia standardised aqueous root extract–Physta® on testosterone levels and quality of life in ageing male subjects... Male (50–70 years) with testosterone level <300 ng/dL 100mg & 200mg
  • Significant increase in the total testosterone levels at week 12 in the Physta® 100 mg group and at weeks 4, 8 and 12 in the Physta® 200 mg group compared to placebo
  • Significant increase at weeks 4, 8 and 12 in the Physta®100 mg group and at weeks 2, 4, 8 and 12 in the Physta® 200 mg group (WG)
  • AMS and FSS showed significant reduction in total scores at all time-points (WG, BG)
  • DHEA levels significantly increased from week 2 onwards (WG)
  • Cortisol levels significantly decreased in the Physta® 200 mg group
  • Muscle strength significantly increased in both Physta® groups at week 12 (WG)
 Chinnappan, S. M., George, A., Pandey, P., Narke, G., & Choudhary, Y. K. (2021). Food & nutrition research, 65, 10-29219. View Study
17 The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males Healthy young males 600mg
  • Significant interaction and time effects for testosterone, free testosterone and estradiol levels in the treatment group but not for luteinising hormone, follicle-stimulating hormone and sexual hormone-binding globulin
 Chan, K. Q., Stewart, C., Chester, N., Hamzah, S. H., & Yusof, A. (2021). Andrologia, 53(4), e14001. View Study
18 Effect of Eurycoma longifolia standardized water extract (Physta®) supplementation on menopausal quality of life and psychological mood states of peri-and postmenopausal women Women (40–55 years) with menopausal symptoms 50mg & 100mg
  • After 12 weeks, participants receiving Physta® at 100mg showed greater reduction of total mean scores of MENQOL and total mood disturbance of POMS followed by Physta® at 50mg compared to placebo.
 Muniandy S, Yahya HM, Shahar S. BMJ open. 2023 Nov;13(11):e073323. View Study
19 Combined Effects of Eurycoma LongifoliaJack Supplementation and A CircuitTraining Programme on Bone MetabolismMarkers, Muscular Strength and Power... Male (35 - 55 years) 400mg
  • ElJEx insed knee extension peak torque at 60o.s-1, shoulder flexion average power at 300o.s-1 and shoulder extension average power at 300o.s-1
  • Ex alone could only increase shoulder extension average power at 300o.s-1
  • Combination of circuit training with Eurycoma longifolia Jack (ElJEx) elicited more beneficial effect on isokinetic muscular strength and power thancircuit training alone (Ex)
 International Journal of Engineering Research and Sports Science View Study
20 Effects of Supramaximal Eccentric Training and Eurycoma Longifolia Jack Supplementation on Quadriceps Strength in Elite Athletes Rugby athletes 400mg
  • Significant interaction of testosterone
  • 1RM concentric, 1RM eccentric, muscle thicknesses of vastus medialis, vastus lateralis, and rectus femoris have produced significant changes
 European Journal of Molecular & Clinical Medicine View Study
21 Effects of Eurycoma Longifolia Jack Supplementation Combined with Resistance Training on Isokinetic Muscular Strength and Power... Physically healthy males (19 - 25 years) 200mg
  • Mean average power of knee flexion at 300°/s in the RT and ElJ & RT groups was significantly higher in the posttest compared with pretest.
  • Wingate relative peak power in the RT group increased significantly compared with respective pretest value, whereas peak power in the combined ElJ & RT group was significantly higher in posttest compared with pretest.
 International Journal of Preventive Medicine View Study
22 Effects of Eurycoma longifolia Jack supplementation on eccentric leg press exercise-induced muscle damage in rugby players Elite male rugby athletes 400mg
  • Significant decreases in PP, jump height, and RSI were observed at 24 hours after exercise compared to baseline
  • Plasma CK activity increased from the baseline (512 ± 265 IU/L) at 24 and 48 hours after exercise
  • Muscle soreness increased at 0.5, 24 and 48 hours after exercise and returned to the baseline by 72 hours after exercise
 Biology of Sport View Study
23 Effects of Eurycoma longifolia on Natural Killer Cells and Endurance Running Performance Recreational athletes 150mg
  • Natural killer (NK) cells count was significantly higher at the end of the EL trial compared to the P trial (4.8 and 4.0 x 103.dL-1 respectively)
 International Journal of Sports Science View Study
24 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function... Men (45-55 years) 200 mg
  • Erectile function demonstrated improvements in both interventions; however, the most significant results were obtained by men allocated to concurrent training + Eurycoma longifolia.
 Maturitas, 2021 Mar:145:78-85 View Study
25 The ergogenic effects of Eurycoma longifolia Jack: a pilot study Healthy men 100mg
  • Improvement in lean body mass of the treatment group showed a significant increment
  • Percentage body fat was significantly decreased
  • 1RM test showed a significant increase
  • Increase in strength in the treatment group was larger than in the placebo group
  • Mean frequency of sEMG on the biceps decreased significantly
  • 2.92% greater reduction in electrical activity of the muscle
  • Arm circumference increased significantly by 1.8 cm after the supplementation
 Br J Sports Med View Study
26 Effects of strength training and Tongkat Ali (Eurycoma longifolia) supplementation on strength and muscle size in middle-aged women Middle age women (45-59 years) 100mg
  • Significant improvement in bench press & leg press
  • Greater gains in handgrip strength and rectus femoris cross-sectional areas
 Proceeding 4th Asia Pacific Conference on Exercise & Sport Science View Study